Заключение
Трансгенные линии Drosophila воспроизводят многие ключевые признаки НДЗ. В то же время, не следует ожидать, что на этих моделях будут полностью повторены все особенности болезней человека.
Пожалуй, моделирование НДЗ на Drosophila должны рассматриваться как создание чувствительной генетической системы, которая предоставляет возможность быстро и сравнительно недорого выявлять клеточные процессы, вовлеченные в патогенез заболеваний, генетические модификаторы этих процессов, а также тестировать потенциальные терапевтические агенты на многоклеточном организме. Конечно, обязательным условием является проверка открытых на Drosophila новых механизмов и молекул на моделях млекопитающих. Открытие генетических модификаторов в Drosophila поможет выявить соответствующие гены у человека и, следовательно, новые терапевтические мишени.Литература
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